To add to Andy Busch's anti-Obamacare focus (highlighted by Julie below) read Matt Spalding on the connection between the Declaration's denunciation of the old despotism of Britain and the bureaucracy's new despotism: 

The greatest political revolution since the American Founding has been the shift of power away from the institutions of constitutional government to an oligarchy of unelected experts. They rule over virtually every aspect of our daily lives, ostensibly in the name of the American people but in actuality by the claimed authority of science, policy expertise, and administrative efficiency....  

Either the party of the modern state will unify its control and solidify its centralized model of government, or a new coalition of its opponents -- unified by a healthy contempt for bureaucratic rule and a determination to reassert popular consent -- will gain control of the political institutions of government and begin the difficult task of restoring real limits on government.